Field mice are able to live any place that a human can survive, including human homes, sheds, barns, open fields, forests, plains, swamps, meadows, mountains and mine shafts. They are very common in the wild but are usually not too far from man-made buildings. Field mice prefer to nest in human structures, especially in winter months, but will also nest outdoors during warm months.

Field mice construct nests. Nests are made from shredded paper, leaves and other soft materials. The average nest is 4 to 6 inches in diameter. In a human dwelling, nests are found in rafters, stored clothing and artificial Christmas trees. Outdoor nests are usually near the ground, in wall cracks or near large rocks. Nesting outdoors allows the mouse to burrow and create a network of tunnels. In these tunnels, a mouse can create separate rooms, used for nesting and storing food. To prevent an ambush, field mice create multiple exits from their tunnels, so they can make a quick exit if needed. Field mice generally stay within 50 feet of their nest.

Field mice vary in appearance based on the specific species but are typically brown, black or white in color. According to Orkin, baby field mice are born blind, deaf and bald.