A boxer-Great Dane mix is a breed of dog known as a "designer dog" or "hybrid dog" and comprises characteristics from both the boxer breed and the Great Dane breed. This mixed dog will have characteristics from its purebred parents, although it is impossible to know which characteristics the dog will inherit.

The boxer-Great Dane mix will range in size from the Great Dane's high 28 to 34 inches tall to the boxer's more medium height at 21 to 25 inches tall. The boxer is well known for its desire for human affection while the Great Dane is well known for its gentle nature.