The platypus is typically attacked by crocodiles, foxes, cats, dogs and large birds of prey, though they can also be attacked by water-rats and pythons. A platypus will attempt to protect itself by burrowing or by using its sharp spines that are located on the back of its legs.

These spines contain poisonous venom that is lethal to many animals, though it is not lethal to humans. The platypus preys on aquatic insects, worms, pea-shell muscles and shrimp. They use their bill to find their prey and then to eat it. The bills are oddly shaped and look like a duck, but actually have receptors which allow the platypus to sense movement.

The platypus has also had to deal with threats from humans. Humans have destroyed much of the platypuses habitat along the rivers and streams where they live. Humans have placed paths along these water areas that cause erosion and give predators better access to platypus burrows. This interference in the platypus environment also makes it more difficult for the platypus to find and capture prey. There is also a high level of toxins from household wastes and fertilizers that make their way into the platypuses environment through the water. To make a difference in the lifestyle of the platypus, people must make an effort to clean up the waterways.