Although a female toy poodle can become pregnant during her first heat, which may come as early as 6 months old, it is safer to wait until she is at least 2 years old. Toy poodles are usually retired from breeding at 5 or 6 years old.

Before breeding, both the male and female dogs should be checked out by a veterinarian and screened for genetic conditions and temperament to ensure high-quality puppies. Breeding should be carefully planned, as puppies require a large commitment of time and finances.

The best time to breed a female toy poodle is about a week after her heat cycle begins. Most breeders allow at least three or four pairings to ensure a successful breeding.