The game "The Last of Us" takes place in seven different locations across the post-apocalyptic United States: Austin, Boston, Lincoln, Pittsburgh, Jackson, Boulder and Salt Lake City. The game begins with the two protagonists meeting in Boston, Mass., though the majority of the first chapter deals with flashbacks in Austin, Texas.

The protagonists spend most of the game on the run from the military in a post-apocalypse situation, where they travel across the United States in search of sanctuary. The game received overwhelmingly positive reviews from critics, including a 95/100 score from Metacritic and a 95 percent positive ranking from GameRankings.